Jesse Jacobs is a Canadian cartoonist and illustrator based in London, Ontario.
Jacobs was born in Moncton, New Brunswick. Early in his career, he worked in animation, notably on the Cartoon Network show Adventure Time. He has also experience as a game developer, although his main arena remains comics.
Jacobs is known for his psychedelic and geometrical style of cartooning. A number of his short comics have been featured in various editions of Fantagraphics annual anthology Best American Comics from 2012 to 2018. Most of his longer books have been published by the Canadian small press publisher Koyama Press, such as By This Shall You Know Him (2012), Safari Honeymoon (2014) and the Eisner nominee (for best new album) Crawl Space (2017).