In 1978, Laurie Strode survived an encounter with Michael Myers, a masked figure who killed her friends and terrorized the town of Haddonfield, Illinois on Halloween night. Myers was later gunned down, apprehended and committed to Smith's Grove State Hospital.

For forty years, memories of that nightmarish ordeal have haunted Laurie and now Myers is back once again on Halloween, having escaped a routine transfer, leaving a trail of bodies in his wake. This time, Laurie is prepared with years of survival training to protect herself, her daughter Karen and her granddaughter Allyson, a teenager separated from her family and enjoying Halloween festivities.