The girl once known as Katie Lopez has transformed into Carmine, a strong and benevolent Queen who's forged New Los Angeles into a safe haven on the West Coast. Only within her borders are the mutated Variants secure and sane.

The quiet cannot last, however. Not while the power-hungry Infected hate without reason.

With help from a mythical warrior known as the Outlaw, Carmine and her staggering city must find the strength to endure the brutal battles storming on the horizon. However, dangerous enemies are already within her walls, striking at those she loves. They know that if she Queen falls, so does all hope for a peaceful future.