Religious artifacts from every faith are disappearing without a trace. The identity of the perpetrator is a complete mystery until Hellboy and Liz Sherman -- acting on an unlikely tip from a ghost -- foil a museum heist attempted by crude, robotic constructs inhabited by human spirits.

One of these freed human spirits offers to help Hellboy track down those who imprisoned him: a fanatical order of psychics obsessed with creating a new messiah, one that will bring about a new stage of evolution for mankind -- whether mankind is willing or not. Now only Hellboy and his colleagues stand between a vulnerable humanity and an evil, vengeful god.