Jennifer Plummer and the Divine Flesh have exactly three things in common: 1) they're trapped inside Jennifer's body; 2) they despise each other; and 3) they're in love with Daryl Plummer, Jennifer's ex-husband.

But when Jennifer takes an experimental wonder drug to free herself from the Divine Flesh's control, it only makes things worse. Expelled from Jennifer's body, the Divine Flesh can now "love" everyone in existence to death, which in this case, means being assimilated forever into the beast.

With time running out, it's somehow up to Jennifer and Daryl to save the universe from complete and total destruction. Can a dysfunctional drug mule and an electrician from rural Idaho stop the cosmic abomination before it's too late? Jennifer thinks, maybe.