What will the Superior Spider-Man do when he encounters the Marvel Universe's greatest heroes and villains? Challenge them, of course! And first up is the Scarlet Spider! Kaine returns to New York to check on Peter's "superior" behavior, not realizing that Doc Ock has taken over Peter's life. But Ock sure knows who Kaine is...he's the man who once killed him! But when their reunion is interrupted by an army of mutant spider-clones, can Spider-Man and Kaine put aside their differences to deal with the Jackal? Plus, as Thanos' forces set their sights on earth, the Superior Spider-Man stands ready to defend his turf! And for months, Spider-Man has been capturing the members of the Sinister Six...but why? Is Doctor Octopus finally showing his true colors? Everything has been building to this!

Collecting: Superior Spider-Man Team-Up 1-4, Scarlet Spider 20