The story of a young woman accused of witchcraft and murder by supernatural means.

In San Francisco, Emily Blake and her husband David, a dermatologist, by an old Victorian in Pacific Heights and hope to start a family. Emily's happy plans are threatened when David begins an affair with a beautiful patient named Jennie.

A visit to a mysterious young boy in the Mission District named Lupe starts a chain of events in motion that result in Jennie's death -- by spontaneous combustion -- a murder trial, a media circus, and demon possession.